1-(1H-pyrrolo[2,3-b]pyridin-4-yl)methanamine

1-(1H-pyrrolo[2,3-b]pyridin-4-yl)methanamine - Names and Identifiers

Name	1-(1H-pyrrolo[2,3-b]pyridin-4-yl)methanamine
Synonyms	(1H-Pyrrolo[2,3-b]pyridin-4-yl) 1H-Pyrrolo[2,3-b]pyridine-4-methanamine (1H-pyrrolo[2,3-b]pyridin-4-yl)methanamine 1-(1H-Pyrrolo[2,3-b]pyridin-4-yl)methanamin 1-(1H-pyrrolo[2,3-b]pyridin-4-yl)methanamine
CAS	888498-07-5
InChI	InChI=1/C8H9N3/c9-5-6-1-3-10-8-7(6)2-4-11-8/h1-4H,5,9H2,(H,10,11)

1-(1H-pyrrolo[2,3-b]pyridin-4-yl)methanamine - Physico-chemical Properties

Molecular Formula	C8H9N3
Molar Mass	147.18
Density	1.278±0.06 g/cm3(Predicted)
Melting Point	131.7-133.0℃
pKa	14.09±0.40(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.712

1-(1H-pyrrolo[2,3-b]pyridin-4-yl)methanamine - Introduction

1-(1H-Pyrrolo [2,3-b]pyridin-4-yl)methanamine(1-(1H-Pyrrolo [2,3-b]pyridin-4-yl)methanamine), often abbreviated as APPA, is an organic compound. The following is a description of the nature, use, method and safety information of APPA:

Nature:
-Appearance: APPA is a white to light yellow crystalline solid.
-Solubility: It is insoluble in water, but can be dissolved in organic solvents (such as chloroform and dichloromethane).
-Melting point: The melting point of APPA is approximately between 130-135°C.

Use:
-Chemical research: APPA is used as an intermediate in the synthesis of biologically active compounds.
-Drug research: Because APPA has some special structural characteristics, it also has certain potential in drug research.

Preparation Method:
The preparation method of APPA can be carried out through the following steps:
1. First, under appropriate conditions, indole and aminocarbaldehyde are reacted to form 4-(methoxymethyl) indole (also known as "methoxymethylindole").
2. Then, 4-(methoxymethyl) indole is reacted with ammonium bromide to form 4-aminomethylindole.
3. Finally, 4-aminomethylindole was reacted with ammonia chloride to obtain the final product 1-(1H-pyrilol [2,3-b]pyridin-4-yl)methanamine(APPA).

Safety Information:
- APPA has reported no apparent toxicity or risk.
-However, as a chemical substance, it is still necessary to comply with normal laboratory safety practices and wear appropriate personal protective equipment (e. g. laboratory gloves, protective glasses, etc.).
-If you accidentally touch or inhale APPA, you should wash the affected area in time and seek medical help if necessary.
- APPA should be kept away from fire and oxidizing agents and stored in a closed container.

Last Update：2024-04-09 21:01:54